Overview
Cu²⁺-Histidine is a prototype MDC engineered to address oxidative stress in neurological disorders. Copper ions provide redox modulation while histidine aids in cellular uptake and targeting of inflamed or ischemic tissue zones.
Mechanism of Action
- Redox cycling of Cu²⁺ interacts with reactive oxygen species (ROS)
- Timed ligand dissociation releases Cu²⁺ in response to oxidative microenvironments
- Histidine serves as a chelating guide for enhanced BBB penetration
Key Properties
- ROS-triggered release dynamics
- Suitable for chronic inflammation targeting
- Demonstrated stability in simulated CSF (cerebrospinal fluid)
Application
Therapeutic Class: Neurodegenerative Disorders
Intended for diseases such as Alzheimer's, Parkinson's, and post-stroke inflammation management.
Neuro
ROS-Responsive
Development Stage
Preclinical Evaluation
Further Information
For licensing details, experimental data, or formulation assistance, contact our research team.
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