Metal Coordination Strategies for Drug Optimization
Our flagship paper explores programmable chelation, ligand switching, and pH-redox activation in metal-drug complexes across five therapeutic classes. This work lays the foundation for the next generation of context-aware therapeutics.
Collaboration Opportunities
We're seeking reviewers and collaborators with expertise in:
- Metal coordination chemistry
- Drug delivery systems
- Computational chemistry
- Redox-responsive therapeutics
Metal Drug Complex (MDC) Publications
Logic-Gated Zinc Complexes in Viral Inhibition
PendingDemonstrates how zinc-ligand MDCs inhibit viral replication through logic-driven docking behavior with pH-dependent activation mechanisms.
Theranostic Ru-MDCs for Tumor Microenvironment Sensing
PendingTracks the activation, fluorescence, and clearance patterns of tumor-specific ruthenium MDCs in preclinical models.
Computational Discovery of Drug-Metal Interactions
Peer ReviewGNN-based prediction of binding geometry, Monte Carlo screening of ligand-metal affinity, and molecular dynamics for in vivo behavior prediction.
Logic-Gated Delivery in MDCs for Oncology
Open CollaborationA proposed framework for tumor-targeted MDCs that activate under acidic, ROS, or enzymatic conditions. Includes self-degrading ligands and metal-release kinetics.
Functional Drug Complex (FDC) Publications
Programmable Ligand-Peptide Interfaces
PendingDescribes ligand-peptide logic chains for adaptive therapeutic response with engineered conditional activation pathways.
RNA-Guided Molecular Folding in FDCs
Under SubmissionSimulation-driven folding of RNA-linked FDCs for shape-dependent activation with applications in controlled release systems.
Contribute to MetalDrug Research
Join our research community as a collaborator, reviewer, or potential co-author. All contributors are acknowledged in publications and may be invited to join ongoing research projects.